In Mass Effect 2 the character goes through a 'nanotech' medical process to heal some severe injuries Shepard suffers early on in the game.
One side-effect of the process is that the process somehow reacts to the decisions the character makes; the more brutal/violent the character is (called "Renegade" decisions in the game), the more small glowing cracks appear on the characters face, and eventually the eyes become glowing yellow with black sclera (whites). If you make more diplomatic/non-violent decisions ("Paragon") the cracks slowly dissapear until they are gone.
For my 'base' play through, I always try to make mostly 'Paragon' decisions; but to get my money's worth out of the game I then go back through and make all the 'Renegade' decisions, just to see how the game plays out ^_^
This took a little work, as I had to modify the textures from a 'magma' elemental skin to have just the red glowing cracks to show.
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